| MLO Description | |
|---|---|
| MLO | Gemini of cajal body |
| Synonym | Gemini of coiled bodies, Nuclear gems |
| Description | Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of proteinaceous membrane-less organelles located in Nucleus of spherical shape. It does not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors[1]. Double-label immunofluorescence microscopy using antibodies against SMN as a marker of Gems, and p80-coilin as a marker of Cajal bodies, revealed that Gems and Cajal bodies mostly colocalize in some cell lines and adult tissues but are separate in fetal tissues and several types of cultured cells. The interaction between Gems and Cajal bodies may be mediated, at least in part, by the capacity of SMN and coilin to bind each other. The Gemins colocalize with SMN in Gems and are also present throughout the cytoplasm and, albeit at lower levels, in the nucleoplasm[2]. |
| Reference | 27838525,15120993 |
Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases