PhaSeDis: A manually curated database of the relations between phase separation and diseases

Liquid-liquid phase separation (LLPS) plays an important role in the temporal and spatial regulation of various biological processes, and emerging evidence supports that LLPS might serve as the underlying mechanism of membraneless organelle (MLO) assembly. Dysfunction of LLPS and MLOs are associated with various pathological processes. PhaSeDis aims to gather LLPS and MLOs related diseases from the dispersed literature. Each entry was assigned with one of the three evidence levels based on original publication: Direct experiment, Indirect experiment, Clinical Investigation. PhaSeDis not only recorded the functional factors, changes of MLOs/LLPS droplets and changes of the factors according to the original publication, but also includes the components of MLOs and small molecules that target the LLPS factors with low-throughput and high-throughput evidences
(go to About for detail).