MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases
Membraneless organelles (MLOs) play important roles in the temporal and spatial regulation of
various biological processes, and emerging evidence supports that liquid-liquid phase separation
(LLPS) is underlying the assembly of MLOs. Dysfunction of MLOs and LLPS are associated with various
pathological processes.
MloDisDB aims to gather MLOs and LLPS related diseases from the dispersed literature. Each entry was assigned with one of the three evidence levels based on original publication: Direct experiment, Indirect experiment, Clinical Investigation.
The functional factors, changes of MLOs and changes of the factors were recorded, the components of MLOs and LLPS related predictions were integrated (go to About for detail).
Examples: Stress Granule, FUS, Parkinson's disease
Browse
Browse all entries in MloDisDB by combinatorial search. For example you can specify the MLO name and the disease.
MLOs
Explore MloDisDB by MLOs, you can see the description, related diseases and components of the MLO.
Diseases
Explore MloDisDB by diseases, you can see all the diseases included in our database and search by human body systems.
News
2020-09-19: Accepted by Briefings in Bioinformatics.https://doi.org/10.1093/bib/bbaa271
2020-09-14: Each entry was assigned with one of the three evidence levels based on original publication: Direct experiment, Indirect experiment, Clinical Investigation.
2020-06-18: MloDisDB 1.0 is online, 719 relations between MLOs and diseases, 52 relations between LLPS and diseases were included.
Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases