| MLO Description | |
|---|---|
| MLO | PML nuclear body |
| Synonym | PML nuclear bodies, PML bodies, PML body, PML nuclear body, PML-NBs |
| Description | PML-NBs are discrete nuclear foci of 0.2-1.0 μm in diameter that are present in most mammalian cell nuclei. They typically number 1-30 bodies per nucleus, depending on the cell type, cell-cycle phase and differentiation stage.PML-NBs are dynamic structures that undergo significant changes in number, size and position during cell-cycle progression and in response to cellular stresses such as DNA damage and induction of senescence.Recent data suggest that PML-NBs are heterogeneous structures and that different PML-NBs may regulate specific cellular functions according to their protein composition, their position in the nucleus and their mobility. |
| Reference | 17928811 |
Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases