| MLO Description | |
|---|---|
| MLO | Paraspeckle |
| Synonym | Paraspeckles |
| Description | Paraspeckle is a nuclear body in which one of the essential paraspeckle proteins co-localizes with the longer isoform of NEAT1. Paraspeckles are mammal-specific RNA-protein nuclear bodies that regulate gene expression. First described in 2002 as nuclear foci enriched in the marker protein paraspeckle component protein 1 (PSPC1), paraspeckles are now known to contain over 40 different proteins (generally ubiquitously expressed RNA-binding proteins) and one architectural lncRNA, nuclear paraspeckle assembly transcript 1 (NEAT1). Some component proteins mediate critical RNA-protein or protein-protein interactions essential for paraspeckle formation. In addition to these structural components there are several different molecules targeted to paraspeckles, such as various types of RNAs, as well as proteins that are not required to build paraspeckles, but nevertheless may be regulated by them. |
| Reference | 29289458 |
Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases