| MLO Description | |
|---|---|
| MLO | Nucleolus |
| Synonym | Nucleoli |
| Description | The nucleolus is a prominent membraneless organelle residing within the nucleus. The nucleolus has been regarded as a housekeeping structure mainly known for its role in ribosomal RNA (rRNA) production and ribosome assembly. However, accumulating evidence has revealed its functions in numerous cellular processes that control organismal physiology, thereby taking the nucleolus much beyond its conventional role in ribosome biogenesis. Perturbations in nucleolar functions have been associated with severe diseases such as cancer and progeria. mass-spectrometry-based analyses have revealed numerous proteins residing in different compartments of the nucleolus involved in functions other than ribosome biogenesis, suggesting a multidimensional role of the nucleolus. |
| Reference | 29779866 |
Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases