| MLO | Phase separation |
|---|---|
| Class | LLPS |
| Synonyms | Phase transition, Liquid-liquid phase separation |
| Classification | nervous system disease |
|---|---|
| Disease | Alzheimer's disease |
| More Disease Information | |
| Disease | Alzheimer's disease |
|---|---|
| Disease Ontology | DOID:10652 |
| MeSH | D000544 |
| ICD-10-CM | G30 |
| OMIM |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | Phosphorylated or mutant aggregation prone recombinant tau undergoes liquid-liquid phase separation (LLPS),as does high molecular weight soluble phospho-tau isolated from human Alzheimer brain. Droplet-like tau can also be observed in neurons and other cells. We found that tau droplets become gel-like in minutes,and over days start to spontaneously form thioflavin-S-positive tau aggregates that are competent of seeding cellular tau aggregation. | ||||
| Organism | Homo sapiens,Escherichia coli | Cell line or tissue | human brain,E. coli BL21,Sf9 | ||
| Experiment evidence | Indirect experiment | Reference | 29472250 | ||
| In vivo PS evidence | FRAP: Yes | 1,6-hexa treatment: Yes | Spherical shape: Yes | ||
| Fusion&Fission: No | PS role: Self | ||||
| Mutation | tau441 E17 [17 threonine and serine residues along the sequence of tau441 mutated into glutamate to introduce negative charges] | Expression change | - |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: aberrant phosphorylation or disease‐relevant pro‐aggregation mutations lead to tau aggregation. Expression change: - PTM: aberrant phosphorylation or disease‐relevant pro‐aggregation mutations lead to tau aggregation. |
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| Drugs from DrugBank | Lansoprazole Docetaxel Astemizole Adenosine 5'-[gamma-thio]triphosphate Flortaucipir F-18 Paclitaxel | |
|---|---|---|
| Molecules from Binding database(PubChem CID) | 6973999 474789 24221476 34201305 581006 24221484 46634111 4756228 45968691 4756227 740040 24221459 24221448 66629291 474841 24221447 24221440 24221463 834235 551050 34202705 3517 66630484 66631888 24221438 24221458 66629883 24221450 62371 24221442 2422148 | |
| Molecules from PDBBind | 1i8h 4glr 4y32 4y3b 4y5i 5e2v 5e2w 5zia 6fbw 6fi5 | |
| Interference Note | - |
| Pscore overall score | 3.41 | PSPer | 0.41000000000000003 |
|---|---|---|---|
| catGRANULE overall score | 1.72 | R+Y | 0.0223076923 |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases