Navigation bar

MLO Information
Factor Information
Disease information
Description from paper
Mutation, Expression change and PTM of the factor
Related Small Molecules
MLO information
MLO Stress granule
Class MLO-unchanged
Synonyms Stress granules, SGs
Factor information
Factor type protein
Factor name PDI
NCBI Gene ID 64714
UniProt ID Q13087
Disease information
Classification nervous system disease
Disease Alzheimer's disease
More Disease Information
Disease Alzheimer's disease
Disease Ontology DOID:10652
MeSH D000544
ICD-10-CM G30
OMIM
CLOSE
Description from paper
MLO change Size: - Number: - Assembly: -
Dynamic: - Others: -
Description: -
Publication note Wild-type protein disulfide isomerase (PDI) is selectively recruited by liquid droplets of Tau,which significantly inhibits phase separation and stress granule formation of Tau,whereas S-nitrosylation of PDI abrogates the recruitment and inhibition. PDI is observed to be S-nitrosylated in the brain of Alzheimer's disease patients. These findings demonstrate how phase separation of Tau is physiologically regulated by PDI and how S-nitrosylation of PDI,a perturbation in this regulation,leads to disease.
Organism Homo sapiens Cell line or tissue HEK-293T,SH-SY5Y
Experiment evidence Indirect experiment Reference 32087196
In vivo PS evidence FRAP: - 1,6-hexa treatment: - Spherical shape: -
Fusion&Fission: - PS role: -
Mutation, Expression change and PTM of the factor
Mutation p.Cys53Ala,p.Cys56Ala,p.Cys397Ala,p.Cys400Ala Expression change -
PTM Position Residue Modification Modifying enzyme
- - -
Description Mutation: quadruple cysteine mutant only having chaperone activity, significantly inhibit pathological phosphorylation and abnormal aggregation of Tau in cells
Expression change: -
PTM: wild-type PDI is selectively recruited by liquid droplets of Tau, which significantly inhibits phase separation and stress granule formation of Tau, whereas S-nitrosylation of PDI abrogates the recruitment and inhibition.
Drugs from DrugBank -
Molecules from BindingDB(PubChem CID) -
Molecules from PDBBind -
Interference Note -
Protein phase separation related sequence features
see detailed information in PhaSePerd Q13087
Pscore overall score 0.36 PSPer 0.18
catGRANULE overall score 0.06 R+Y 0.0006153846000000001

Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases