| MLO | Stress granule |
|---|---|
| Class | MLO-unchanged |
| Synonyms | Stress granules, SGs |
| Classification | cancer |
|---|---|
| Disease | Chronic myeloid leukemia |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | BCR-ABL is localized to stress granules and that its granular localization contributes to BCR-ABL-dependent leukemogenesis. Whereas wild-type BCR-ABL rescued the growth defect in IL-3-depleted Ba/F3 cells,mutant BCR-ABL lacking the N-terminal region failed to do so. Forced tetramerization of the N-terminus-deleted mutant could not restore the growth defect,indicating that granule formation,but not tetramerization,through its N-terminus is critical for BCR-ABL-dependent oncogenicity. Our findings together provide new insights into the pathogenesis of chronic myelogenous leukemia (CML) by BCR-ABL and open a window for developing novel therapeutic strategies for this disease. | ||||
| Organism | Homo sapiens | Cell line or tissue | HeLa, K562,Ku812,TOM-1,ALL/MIK,MY,WEHI-3 ,Ba/F3-CL1 | ||
| Experiment evidence | Direct experiment | Reference | 31735741 (2019-12-26) | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | BCR-ABL fusion,N-terminal deletion | Expression change | - |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: Here, we report that BCR-ABL is localized to stress granules and that its granular localization contributes to BCR-ABL-dependent leukemogenesis. Expression change: - PTM: - |
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| Drugs from DrugBank | - | |
|---|---|---|
| Molecules from BindingDB(PubChem CID) | 44395746 6401485 4621663 4395789 4395763 4395745 6401486 6401491 6401482 6401490 6401489 7214623 4395813 6401502 6401503 6401487 44241 6401488 6401483 6401501 0772051 6401495 6401497 6401492 6401494 4395926 4395904 1316850 6401500 6401498 1488124 4395880 | |
| Molecules from PDBBind | - | |
| Interference Note | - |
| Pscore overall score | 3.03 | PSPer | 0.26 |
|---|---|---|---|
| catGRANULE overall score | 0.96 | R+Y | 0.096 |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases