| MLO | Stress granule |
|---|---|
| Class | MLO-unchanged |
| Synonyms | Stress granules, SGs |
| Classification | nervous system disease |
|---|---|
| Disease | Frontotemporal dementia |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | Insoluble,hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal dementia and ALS in many individuals with these neurodegenerative diseases. In human embryonic kidney HEK293E cells,various SG-forming conditions induced very strong TDP-43 ubiquitylation,insolubility,and reduced splicing activity. Osmotic stress-induced SG formation and TDP-43 ubiquitylation occurred rapidly and coincided with colocalization of TDP-43 and SG markers. Pathological TDP-43 modifications can be mediated via multiple distinct pathways for which SGs are not essential. | ||||
| Organism | Homo sapiens | Cell line or tissue | HEK293E,HeLa | ||
| Experiment evidence | Indirect experiment | Reference | 31780563 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | - |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: - PTM: Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal dementia and ALS in many individuals with these neurodegenerative diseases. |
||
| Drugs from DrugBank | - | |
|---|---|---|
| Molecules from BindingDB(PubChem CID) | 45223816；121380360；56739767；863；4212；6112 | |
| Molecules from PDBBind | - | |
| Interference Note | - |
| Pscore overall score | 5.95 | PSPer | 0.38 |
|---|---|---|---|
| catGRANULE overall score | 2.04 | R+Y | 0.0018461538000000002 |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases