| MLO | Paraspeckle |
|---|---|
| Class | MLO-unchanged |
| Synonyms | Paraspeckles |
| Classification | nervous system disease |
|---|---|
| Disease | Parkinson's disease |
| More Disease Information | |
| Disease | Parkinson's disease |
|---|---|
| Disease Ontology | DOID:14330 |
| MeSH | D010300 |
| ICD-10-CM | G20 |
| OMIM |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | The numbers of TH+ neurons significantly decreased in PD mice compared with the control. The expressions of NEAT1,PINK1 protein and LC3-II/LC3-I level were increased by MPTP in vitro and in vivo. Moreover,NEAT1 positively regulated the protein level of PINK1 through inhibition of PINK1 protein degradation. And NEAT1 mediated the effects of MPP+ on SH-SY5Y cells through stabilization of PINK1 protein. The results of in vivo experiments revealed that NEAT1 knockdown could effectively suppress MPTP-induced autophagy in vivo that alleviated dopaminergic neuronal injury. | ||||
| Organism | Mus musculus | Cell line or tissue | SH-SY5Y | ||
| Experiment evidence | Indirect experiment | Reference | 29287722 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | up |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: The expressions of NEAT1,PINK1 protein and LC3-II/LC3-I level were increased by MPTP in vitro and in vivo. PTM: - |
||
| Pscore overall score | - | PSPer | |
|---|---|---|---|
| catGRANULE overall score | - | R+Y | |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases