| MLO | Paraspeckle |
|---|---|
| Class | MLO-changed |
| Synonyms | Paraspeckles |
| Classification | nervous system disease |
|---|---|
| Disease | Amyotrophic lateral sclerosis |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: promote | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. | |||||
| Publication note | NEAT1_2 lncRNA may act as a scaffold of RNAs and RNA binding proteins in the nuclei of ALS motor neurons,thereby modulating the functions of ALS-associated RNA-binding proteins during the early phase of ALS. These findings provide the first evidence of a direct association between paraspeckle formation and a neurodegenerative disease,and may shed light on the development of novel therapeutic targets for the treatment of ALS. | ||||
| Organism | Homo sapiens | Cell line or tissue | HeLa | ||
| Experiment evidence | Indirect experiment | Reference | 23835137 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | up |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: Analyses of 633 human spinal motor neurons in six ALS cases showed NEAT1_2 lncRNA was upregulated during the early stage of ALS pathogenesis. PTM: - |
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| Pscore overall score | - | PSPer | |
|---|---|---|---|
| catGRANULE overall score | - | R+Y | |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases