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MLO Information
Factor Information
Disease information
Description from paper
Mutation, Expression change and PTM of the factor
Related Small Molecules
MLO information
MLO Postsynaptic density
Class MLO-changed
Synonyms PSD, postsynaptic membrance density
Factor information
Factor type protein
Factor name GSK-3
NCBI Gene ID 173149
UniProt ID Q9U2Q9
Disease information
Classification nervous system disease
Disease Memory deficits
More Disease Information
Disease Memory deficits
Disease Ontology -
MeSH D008569
ICD-10-CM -
OMIM
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Description from paper
MLO change Size: thinner Number: - Assembly: -
Dynamic: - Others: -
Description: The LTP-associated synapse impairments including less presynaptic active zone, thinner postsynaptic density, and broader synaptic cleft were also prominent in the hippocampal slices after HFS with activation of GSK-3.
Publication note Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in Alzheimer's disease,the most common age-associated dementia. In postsynaptic level,the expression of PSD93 and NR2A/B proteins decreased significantly when GSK-3 was activated. The LTP-associated synapse impairments including less presynaptic active zone,thinner postsynaptic density,and broader synaptic cleft were also prominent. We conclude that upregulation of GSK-3 impairs the synaptic plasticity both functionally and structurally,which may underlie the GSK-3-involved memory deficits.
Organism Rattus norvegicus Cell line or tissue brain tissues
Experiment evidence Indirect experiment Reference 17989287
In vivo PS evidence FRAP: - 1,6-hexa treatment: - Spherical shape: -
Fusion&Fission: - PS role: -
Mutation, Expression change and PTM of the factor
Mutation - Expression change up
PTM Position Residue Modification Modifying enzyme
- - -
Description Mutation: -
Expression change: Upregulation of GSK-3 impairs the synaptic plasticity both functionally and structurally,which may underlie the GSK-3-involved memory deficits.
PTM: -
Drugs from DrugBank -
Molecules from Binding database(PubChem CID) -
Molecules from PDBBind -
Interference Note -
Protein phase separation related sequence features
see detailed information in PhaSePerd Q9U2Q9
Pscore overall score - PSPer
catGRANULE overall score - R+Y

Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases