| MLO | Nuclear pore complex |
|---|---|
| Class | MLO-unchanged |
| Synonyms | Nuclear pore complexes, NPC, NuPC |
| Classification | nervous system disease |
|---|---|
| Disease | Major depressive disorder |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | Genetic evidence suggests cell-type-specific functions for certain nucleoporins,and gene expression profiling has revealed that nucleoporin p62 (NUP62) transcripts are decreased in the prefrontal cortex of major depressives. At least two types of mechanisms--one affecting expression and the other association with the NPC--could contribute to loss of NUP62 from CA3 pyramidal neurons during chronic stress. Their combined actions may account for the enhanced responsiveness of CA3 apical dendrites to chronic stress and may either be pathogenic or serve to protect CA3 neurons from permanent damage. | ||||
| Organism | Homo sapiens,Rattus norvegicus | Cell line or tissue | S12,Hippocampus and neocortex | ||
| Experiment evidence | Indirect experiment | Reference | 30361777,25349423 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | down |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: gene expression profiling has revealed that nucleoporin p62 (NUP62) transcripts are decreased in the prefrontal cortex of major depressives. PTM: - |
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| Pscore overall score | 3.54 | PSPer | 0.27 |
|---|---|---|---|
| catGRANULE overall score | 0.44 | R+Y | 0.0 |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases