| MLO | Nucleolus |
|---|---|
| Class | MLO-unchanged |
| Synonyms | Nucleoli |
| Classification | nervous system disease |
|---|---|
| Disease | Parkinson's disease |
| More Disease Information | |
| Disease | Parkinson's disease |
|---|---|
| Disease Ontology | DOID:14330 |
| MeSH | D010300 |
| ICD-10-CM | G20 |
| OMIM |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | We showed that overexpressed hA53T-SNCA localizes to the nucleolus. Moreover,these mutants show a progressive reduction of rDNA transcription linked to a reduced mouse lifespan.mRNA levels of the nucleolar transcription initiation factor 1A (TIF-IA,also known as RRN3) decrease in the substantia nigra of individuals with PD. Because loss of TIF-IA,as a tool to mimic nucleolar stress,increases oxidative stress and because DJ-1 and PINK1 mutations result in higher vulnerability to oxidative stress,we further explored the synergism between these PD-associated genes and impaired nucleolar function. By the conditional ablation of TIF-IA,we blocked ribosomal RNA (rRNA) synthesis in adult dopaminergic neurons in a DJ-1/PINK1 DKO background. However,the early phenotype of these triple knockout mice was similar to those mice exclusively lacking TIF-IA. These data sustain a model in which loss of DJ-1 and PINK1 does not impair nucleolar activity in a pre-symptomatic stage. | ||||
| Organism | Homo sapiens,Mus musculus | Cell line or tissue | Human post-mortem midbrain tissue,mouse midbrain tissue | ||
| Experiment evidence | Indirect experiment | Reference | 28360124 (2017-05-01) | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | down |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: These data sustain a model in which loss of DJ-1 and PINK1 does not impair nucleolar activity in a pre-symptomatic stage. PTM: - |
||
| Pscore overall score | 1.67 | PSPer | 0.25 |
|---|---|---|---|
| catGRANULE overall score | 0.48 | R+Y | 0.0 |
|
|
|||
Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases