| MLO | Postsynaptic density |
|---|---|
| Class | MLO-unchanged |
| Synonyms | PSD, postsynaptic membrance density |
| Classification | nervous system disease |
|---|---|
| Disease | Schizophrenia |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | Our findings describe a unique pathophysiology of specific PSD-95 isoform dysregulation in schizophrenia,chronic neuroleptic treatment,and a genetic lesion mouse model of drastically reduced N-methyl-d-aspartate receptor (NMDAR) complex expression. These data indicate that regulation of PSD-95 is multifaceted,may be isoform specific,and biologically relevant for synaptic signaling function. | ||||
| Organism | Homo sapiens | Cell line or tissue | dorsolateral prefrontal cortex from subjects with schizophrenia | ||
| Experiment evidence | Clinical investigation | Reference | 28126896 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | down |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: NMDAR-mediated synaptic remodeling, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking and interaction may be impaired in schizophrenia by decreased PSD-95 beta and truncated expression (respectively). PTM: - |
||
| Drugs from DrugBank | - | |
|---|---|---|
| Molecules from BindingDB(PubChem CID) | 25062887 4568997 4568835 4568793 4568788 4568836 4568811 4568834 4568938 4568998 1935893 4568992 4569003 4568789 4568937 4568810 4568833 4568787 4568837 4568808 4568990 5062886 4568794 4568812 4568795 4568993 1619578 | |
| Molecules from PDBBind | 5j7j | |
| Interference Note | - |
| Pscore overall score | 1.28 | PSPer | 0.26 |
|---|---|---|---|
| catGRANULE overall score | 1.12 | R+Y | 0.0069230769 |
|
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases