| MLO | Nuclear pore complex |
|---|---|
| Class | MLO-unchanged |
| Synonyms | Nuclear pore complexes, NPC, NuPC |
| Classification | other diseases |
|---|---|
| Disease | Early dystrophic cardiac remodelling |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | Beyond the control of nuclear-cytoplasmic trafficking nucleoporins regulate gene expression and are involved in cardiac diseases. Notably,a number of cardiovascular disorders have been linked to alterations in epigenetic mechanisms. Here we aimed to determine the contribution of Nup153 to the epigenetic alterations occurring in cardiomyopathy of dystrophin-deficient mdx mice (C57BL/10ScSn-Dmd mdx /J). Importantly,Nup153 up-regulation and increased acetylation were also found in the heart of Duchenne muscular dystrophy patients. Our data indicate that Nup153 is an epigenetic regulator which,upon altered NO(nitric oxide) signalling,mediates the activation of genes potentially associated with early dystrophic cardiac remodelling. | ||||
| Organism | Homo sapiens,Mus musculus | Cell line or tissue | H9c2,HL-0 | ||
| Experiment evidence | Indirect experiment | Reference | 32209327,28513807 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | up |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: Nup153 up-regulation and increased acetylation were also found in the heart of Duchenne muscular dystrophy patients. Lysine acetyl transferase (KAT) activity associated with Nup153 was higher in mdx hearts paralleling increased binding with the lysine acetylases P300/CBP-associated factor (PCAF) and p300. PTM: lysine acetyl transferase (KAT) activity associated with Nup153 was higher in mdx hearts paralleling increased binding with the lysine acetylases P300/CBP-associated factor (PCAF) and p300. |
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| Pscore overall score | 5.51 | PSPer | 0.42 |
|---|---|---|---|
| catGRANULE overall score | 1.51 | R+Y | 0.0476923077 |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases