| MLO | Stress granule |
|---|---|
| Class | MLO-changed |
| Synonyms | Stress granules, SGs |
| Classification | other diseases |
|---|---|
| Disease | Inclusion body myositis |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: defective disassembly | ||||
| Description: VCP dysregulation and defective stress granule disassembly contribute to inclusion body myositis (IBM) -like disease in Ulk1/2-deficient mice. | |||||
| Publication note | ULK1/2 localize to stress granules and phosphorylate VCP,thereby increasing VCP's activity and ability to disassemble stress granules. Disrupted expression of the core autophagy proteins ULK1 and ULK2 in mice causes a vacuolar myopathy with ubiquitin and TDP-43-positive inclusions. VCP dysregulation and defective stress granule disassembly contribute to inclusion body myositis (IBM) -like disease in Ulk1/2-deficient mice. ULK1/2 as targets for exploiting the higher-order regulation of stress granules for therapeutic intervention of IBM and related disorders. | ||||
| Organism | Homo sapiens,Mus musculus | Cell line or tissue | HEK293T,U2OS,HeLa,C2C12 | ||
| Experiment evidence | Direct experiment | Reference | 30979586 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | down |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: VCP dysregulation and defective stress granule disassembly contribute to IBM-like disease in Ulk1/2-deficient mice PTM: - |
||
| Drugs from DrugBank | - | |
|---|---|---|
| Molecules from Binding database(PubChem CID) | 176167 23631 47077 1656518 025986 809715 291 1314340 2945601 0427712 08908 918852 66631440 329102 0127622 76870 886808 5983966 4905147 55531579 0138259 287969 1712649 18905544 6725726 1448975 1667893 038525 18905943 0184653 081361 9225335 829523 929127 16 | |
| Molecules from PDBBind | 6qat 6qau 6qav | |
| Interference Note | - |
| Pscore overall score | 3.05 | PSPer | 0.31 |
|---|---|---|---|
| catGRANULE overall score | 0.59 | R+Y | 0.0203076923 |
|
|
|||
Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases