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MLO Information
Factor Information
Disease information
Description from paper
Mutation, Expression change and PTM of the factor
Related Small Molecules
MLO information
MLO P-body
Class MLO-changed
Synonyms P-bodies, Processing bodies
Factor information
Factor type protein
Factor name EIF2B5
NCBI Gene ID 8893
UniProt ID Q13144
Disease information
Classification nervous system disease
Disease Leukoencephalopathy with vanishing white matter
More Disease Information
Disease Leukoencephalopathy with vanishing white matter
Disease Ontology DOID:0060868
MeSH -
ICD-10-CM E75.2
OMIM
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Description from paper
MLO change Size: - Number: increase Assembly: -
Dynamic: - Others: -
Description: VWMD mutations had diverse effects on stress-induced assemblies with some alleles altering eIF2B bodies, and others leading to increased P-body formation.
Publication note To examine these issues,we assessed eIF2B body,stress granule,and P-body induction in wild-type yeast cells and cells carrying VWMD alleles in the EIF2B2 (GCD7) and EIF2B5 (GCD6) subunits of eIF2B. We demonstrate eIF2B bodies are rapidly and reversibly formed independently of stress granules during acute glucose deprivation. VWMD mutations had diverse effects on stress-induced assemblies with some alleles altering eIF2B bodies,and others leading to increased P-body formation.
Organism Homo sapiens,S. cerevisiae Cell line or tissue HeLa
Experiment evidence Indirect experiment Reference 30115954
In vivo PS evidence FRAP: - 1,6-hexa treatment: - Spherical shape: -
Fusion&Fission: - PS role: -
Mutation, Expression change and PTM of the factor
Mutation VWMD mutant Expression change -
PTM Position Residue Modification Modifying enzyme
- - -
Description Mutation: VWMD mutations cause hyper-sensitivity to eIF2α phosphorylation and thereby impacting VWMD pathogenesis
Expression change: -
PTM: -
Drugs from DrugBank -
Molecules from Binding database(PubChem CID) -
Molecules from PDBBind -
Interference Note -
Protein phase separation related sequence features
see detailed information in PhaSePerd Q13144
Pscore overall score 1.01 PSPer 0.27
catGRANULE overall score 0.56 R+Y 0.0009230769000000001

Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases