| MLO | Postsynaptic density |
|---|---|
| Class | MLO-unchanged |
| Synonyms | PSD, postsynaptic membrance density |
| Factor type | others |
|---|---|
| Factor name | N-(tert-Butyl) hydroxylamine (NtBuHA) |
| NCBI Gene ID | - |
| UniProt ID | - |
| Classification | nervous system disease |
|---|---|
| Disease | Central nervous system disorders |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: - | |||||
| Publication note | De-palmitoylation by N-(tert-Butyl) hydroxylamine inhibits AMPAR-mediated synaptic transmission via affecting receptor distribution in postsynaptic densities. Our data suggest that the palmitoylation-deficient state initiated by NtBuHA preferentially reduces AMPAR function,which may potentially be used for the treatment of central nervous system (CNS) disorders. | ||||
| Organism | Mus musculus | Cell line or tissue | brain tissues | ||
| Experiment evidence | Clinical investigation | Reference | 29911316 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | - |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: - PTM: - |
||
| Pscore overall score | - | PSPer | |
|---|---|---|---|
| catGRANULE overall score | - | R+Y | |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases