| MLO | Stress granule |
|---|---|
| Class | MLO-changed |
| Synonyms | Stress granules, SGs |
| Classification | nervous system disease |
|---|---|
| Disease | Brain injury |
| More Disease Information | |
| MLO change | Size: - | Number: - | Assembly: promote | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: Traumatic brain injury(TBI) leads to the induction of stress granules (SGs) in the brain. | |||||
| Publication note | Traumatic brain injury(TBI) leads to the induction of stress granules (SGs) in the brain. The degree of SGs induction directly correlates with the level of trauma. Trauma-induced SGs are ubiquitin,p62 and TDP-43 positive,and persistently remain over time suggesting that SGs might be aggregates and exert toxicity in our fly models. TBI on animals expressing ALS-linked genes increased mortality and locomotion dysfunction suggesting that mild trauma might aggravate neurodegenerative symptoms associated with ALS. | ||||
| Organism | Drosophila melanogaster | Cell line or tissue | Drosophila | ||
| Experiment evidence | Direct experiment | Reference | 29432563 | ||
| In vivo PS evidence | FRAP: - | 1,6-hexa treatment: - | Spherical shape: - | ||
| Fusion&Fission: - | PS role: - | ||||
| Mutation | - | Expression change | - |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: - Expression change: - PTM: - |
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| Pscore overall score | - | PSPer | |
|---|---|---|---|
| catGRANULE overall score | - | R+Y | |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases