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MLO Information
Factor Information
Disease information
Description from paper
Mutation, Expression change and PTM of the factor
Related Small Molecules
MLO information
MLO Phase separation
Class LLPS
Synonyms Phase transition, Liquid-liquid phase separation
Factor information
Factor type protein
Factor name TBP
NCBI Gene ID 6908
UniProt ID P20226
Disease information
Classification nervous system disease
Disease Spinocerebellar ataxia type 17
More Disease Information
Disease Spinocerebellar ataxia type 17
Disease Ontology DOID:0050967
MeSH -
ICD-10-CM -
OMIM
CLOSE
Description from paper
MLO change Size: - Number: - Assembly: -
Dynamic: - Others: -
Description: -
Publication note TBP IDR with WT glutamine repeat length (38Q) facilitated phase separation over the CRY2 control in the optoDroplet system, and TBP IDR droplets exhibited liquidlike FRAP rate. In contrast, an SCA17-associated polyglutamine repeat expansion (53Q) inhibited TBP IDR droplet formation.
Organism Homo sapiens Cell line or tissue HEK293T,murine cells
Experiment evidence Indirect experiment Reference 32386547 (2020-05-28)
In vivo PS evidence FRAP: No 1,6-hexa treatment: - Spherical shape: -
Fusion&Fission: - PS role: -
Mutation, Expression change and PTM of the factor
Mutation polyglutamine expansion Expression change -
PTM Position Residue Modification Modifying enzyme
- - -
Description Mutation: an SCA17-associated polyglutamine repeat expansion (53Q) inhibited TBP IDR droplet formation
Expression change: -
PTM: -
Drugs from DrugBank -
Molecules from Binding database(PubChem CID) -
Molecules from PDBBind -
Interference Note -
Protein phase separation related sequence features
see detailed information in PhaSePerd P20226
Pscore overall score 2.13 PSPer 0.31
catGRANULE overall score -0.29 R+Y 0.0009230769000000001

Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases