| MLO | Phase separation |
|---|---|
| Class | LLPS |
| Synonyms | - |
| Classification | cancer |
|---|---|
| Disease | Leukaemia |
| More Disease Information | |
| MLO change | Size: larger | Number: decrease | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: Relative to N-IDR_WT/A9(carrying an N51S homeodomain mutation, its DNA-binding-defective form) formed considerably fewer but larger puncta | |||||
| Publication note | To investigate the roles for IDR and LLPS in leukaemogenesis, we mutated phenylalanine in the FG repeats of chimeras to serine—a mutation previously shown to disable hydrogel formation by FG repeats in vitro. The Phe-to-Ser mutant was unable to establish | ||||
| Organism | Homo Sapiens, Mus musculus | Cell line or tissue | HEK293FT, mouse HSPCs | ||
| Experiment evidence | Direct experiment | Reference | 34163069 | ||
| In vivo PS evidence | FRAP: No | 1,6-hexa treatment: Yes | Spherical shape: Yes | ||
| Fusion&Fission: Yes | PS role: Self | ||||
| Mutation | N51S | Expression change | - |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: Relative to N-IDR_WT/A9(carrying an N51S homeodomain mutation, its DNA-binding-defective form) formed considerably fewer but larger puncta. Expression change: - PTM: - |
||
| Pscore overall score | - | PSPer | |
|---|---|---|---|
| catGRANULE overall score | - | R+Y | |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases