| MLO | Phase separation |
|---|---|
| Class | LLPS |
| Synonyms | - |
| Classification | nervous system disease |
|---|---|
| Disease | Age related macular degeneration |
| More Disease Information | |
| Disease | Age related macular degeneration |
|---|---|
| Disease Ontology | DOID:10871 |
| MeSH | D008268 |
| ICD-10-CM | H35.30 |
| OMIM |
| MLO change | Size: larger | Number: - | Assembly: - | ||
|---|---|---|---|---|---|
| Dynamic: - | Others: - | ||||
| Description: ApoE forms spherical structures with average sphericity approximately 0.9 that readily fuse and relax. There were significantly more ApoE2 condensates with larger volumes (>0.6 μm3), compared with either ApoE3 or ApoE4 condensates. We observed that 1,6-he | |||||
| Publication note | Differential cholesterol transport mediated by ApoE isoforms (ApoE2<<ApoE3=ApoE4, meaning ApoE2 is less efficient at cholesterol transport than ApoE3 or ApoE4, which are roughly equal to each other) regulates RPE susceptibility to complement attack. Furth | ||||
| Organism | Homo sapiens, Mus musculus | Cell line or tissue | primary retinal pigment epithelium, human AMD tissues, mouse | ||
| Experiment evidence | Indirect experiment | Reference | 33822768 (2021-05-10) | ||
| In vivo PS evidence | FRAP: No | 1,6-hexa treatment: Yes | Spherical shape: Yes | ||
| Fusion&Fission: Yes | PS role: Self | ||||
| Mutation | ApoE isoforms (ApoE2, ApoE3, ApoE4) | Expression change | - |
|---|---|---|---|
| PTM | Position Residue | Modification | Modifying enzyme |
| - | - | - | |
| Description | Mutation: ApoE2 exhibits significant defects in intracellular trafficking and cholesterol transport compared with ApoE3 and ApoE4. Complement-regulatory mechanisms were impaired in ApoE2-RPE, likely due to increased tubulin acetylation. There were significantly mor Expression change: - PTM: - |
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| Drugs from DrugBank | - | |
|---|---|---|
| Molecules from Binding database(PubChem CID) | - | |
| Molecules from PDBBind | 6ncn 6nco | |
| Interference Note | We show that upstream therapeutic strategies that restore lipid homeostasis prevent complement activation, protect mitochondrial integrity, and limit phase separation and drusen nucleation in the RPE. Inhibiting cholesterol biosynthesis with the lipophili |
| Pscore overall score | - | PSPer | |
|---|---|---|---|
| catGRANULE overall score | - | R+Y | |
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Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases